Hao Yin @HaoYin@social.cleverlibre.org
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op
Joined Nov 2022
Hao Yin
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After scoping out Mastodon for about a week now, it's probably time for an #introduction
Hi I'm Alex, a Reviews #Editor for @Dev_journal, a community #journal covering #devbio, #stemcells & #regeneration. Development hosts the #devbiol community blog @the_node and is published by the @Co_Biologists.
I'll mostly be tooting about amazing #devbio research and conferences, and occasionally about personal stuff like #books, #reading, #gardening and other adventures on my bike or #kayak.
Hao Yin
boosted
Hi #ScienceMastodon. We, at #Dev_journal, are a #community journal covering #DevBio, #stemcells, #regeneration and more. Development is led by Editor-in-Chief @jamesbriscoe & published by the not-for-profit @Co_Biologists.
We’ll be tooting about our #research papers, #reviews, #interviews, charitable activities, #conferences and #devbiol news from our community site, @the_node.
Toots by Online Editor @helenzsci, Reviews Editor @amjeve & Executive Editor Katherine Brown
Pancreatic Rab11a/Rab11b dKO->
Aberrant polarized transport of apical/basolateral proteins->
AMIS supernumerary->
Defects in ductal #Lumenogenesis; Acinar morphogenesis; Pancreatic cell lineage dysregulation
Highly intriguing, PancRab11KO->⏬Sox9+ bipotent progenitor & #Islet mass-> #GlucoseIntolerance in suvived adult🐭
Lumenized epithelial paracrine or endocrine-autonomous defect?😆
No baseline change in fast glucose. Insulin/glucagon? Adult islet histology-Amyloid degeneration?
The branched, lumenized pancreatic duct is fragmented into disconnected Microlumens + enlarged Cyst in PancRab11KO🐭
Can't help but think Rab35 in anisotropic Lumenogenesis of liver #BileCanaliculi
Is there a primary hydro-osmotic defect here?😋
Still, what happens to pancreatic vascular morphogenesis in Panc-Rab11 KO🐭?(Surely, epithelia & endothelia are coupled🤪)
More importantly, now it's the magic timing if you also want to have such amazing stories
Cleaver lab is recruiting TWO postdocs
Dr. Ondine Cleaver lab @ondinecleaver2022 bioXRiv 2022
https://www.biorxiv.org/content/10.1101/2022.11.17.516976v1
Hao Yin
boosted
Does anybody else find Mastodon to be buggy (slow)? I’m sure it’s the crush of people fleeing the bird site. But wondering if it’s just me.
(Also I realize the servers are maintained by volunteers and not a for-profit company, hence grateful, but curious).
Hao Yin
boosted
Excited to share our preprint on the role of Rab11 in microlumen formation during early pancreas development.
When Rab11 is genetically deleted in pancreatic epithelium:
-intracellular cargo containing apically targeted proteins are stuck in the cell
-Lumens fail
-Branch morphogenesis is defective
-Beta cell mass is reduced
Cool work spearheaded by grad student Haley Barlow. #DevBio #DevBiol #Pancreas #BetaCell #Lumen #SendFeedback
Hao Yin
boosted
The small RNA landscape is stable with age in Drosophila
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0273590
Hao Yin
boosted
🚨JOB ALERT🚨
My lab at University of Maryland-Baltimore is hiring a postdoc!
Consider applying if you are interested in cellular regulators of excitability #ionchannels, mouse brains🧠, CRISPR-Cas9 gene-editing 🧬✂️, and behaviors 🐭
(more info here: https://thejuarezlab.com)!
We are dedicated to the promotion of diversity and inclusivity in science.
We can also connect at #ACNP2022 in December!
#neuroscience #neurojobs #PDjob #URMinSTEM #BlackinNeuro #DSPAN #HHMIGilliam #NeuroMastodon
Hao Yin
boosted
RT @LyssiotisLab
Hyping new @SciImmunology from @_Hanna_Hong (before #Twitter burns down 🔥)
➡️OXPHOS Promotes Apoptotic Resistance and Cellular Persistence in TH17 cells in the Periphery and Tumor Microenvironment ⬅️
Read on for a #tweetorial
http://www.science.org/doi/10.1126/sciimmunol.abm8182
Hao Yin
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New insights on pancreatic morphogenesis from @ondinecleaver@ lab!
Another link between #morphogenesis and #differentiation!
Pre-print 🔗
https://qoto.org/@biorxivpreprint/109366467608301665
Hao Yin
boosted
Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass. https://www.biorxiv.org/content/10.1101/2022.11.17.516976v1?med=mas
Hao Yin
boosted
#cardiology #CardioTooter Future in medicine : Inflammosomes .Targeting the Inflammasome in Cardiovascular Disease
https://www.jacc.org/doi/full/10.1016/j.jacbts.2021.08.006
Airway #SmoothMuscleCell #Asthma Inflammation
SMMHC-driven #Integrin α7 transgene in ovalbumin♀️🐭->
⏬Airway leukocyte infiltration
⏬Pulmonary resistance (not compliance)
Re-balanced cytokine/chemokine production
Dr. Mariam Ba lab FASEB Bioadv 2022
https://faseb.onlinelibrary.wiley.com/doi/10.1096/fba.2022-00050
Some #LongNonCodingRNAs encode functional peptides😎
LncPSR & its protein, Arteridin, complex with Ybx1->
⏬#SmoothMuscleCell contractile phenotype
AAV2-SM22α-shPSR⏬ANGII-induced SMC hypertrophy in🐭aorta
Dr. Y Wang, G Wu, C Zeng labs @CircRes 2022
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.321080
50% tetrahydrofuran in ddH2O to clear🐭🧠etc ≤ 48 h
80% Nycodenz+7M urea-> RI 1.518
Post-clearing cryosectionable, whole-mount immunofluorescence
Minimal volume change
Dr Chih-Wei Hsu & Joshua Wythe labs eLife 2022 @CWLoganHsu @wythelab
https://elifesciences.org/articles/77419
Landmark👹
How fetal liver vasculature serves as a transient niche for #HematopoieticStemCell expansion while undergoing #BranchingMorphogenesis
Fetal liver hematopoietic stem cell niches associate with portal vessels
Dr. Paul Frenette lab Science 2015
https://www.science.org/doi/10.1126/science.aad0084
Hao Yin
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#introduction. Group leader at IRCM. Developmental biologist by training with long standing interest in epithelial polarity and junctions.
In the lab, we study intercellular #signaling in #development and #cancer using primarily #drosophila (a bit of mice and human cancer cell lines).
Main interests:
#devbio #devbiol #DevelopmentalBiology
#physiology #cellbiology #cellbio #mechanobiology
#microscopy #imaging
Other scientific interests
#insects #evolution
#fossil #paleontology #fossilfriday
Hao Yin
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Hao Yin
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Thrilled to share our lab's first paper in which we establish genome-wide CRISPR screening within a single mouse! We are so excited about the power of this platform to enable high-throughput genetic dissection of diverse phenomena within a living mammal.
https://www.cell.com/cell-genomics/fulltext/S2666-979X(22)00170-7
#Senescence #ImmuneSurveillance
Next-gen #Senolytic
#ImmuneCheckpointBlockade activates CD8+ T cytotoxicity against (inflammed🔥) PD-L1+ senescent cells->
⏬adverse phenotypes in🐭#Aging+#NASH
Dr. Yoshikazu Johmura & Makoto Nakanishi labs Nature 2022
https://www.nature.com/articles/s41586-022-05388-4
Hao Yin
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@ondinecleaver2022 @DenisDuboule @opourquie @mads100tist @RogersLabUCD @HaoYin @scottbarolo @kkroll @SpagnoliLab @Mill_lab @jamesbriscoe @MokalledLab @AaronJohnson @ebardot @MarieKmita
Few additions if not overlapping:
@DavidBrueckner (who actually helped many of us to join mastodon!)
@edouardhannezo
@MikiEbisuya
And @knoepfler is here, and was looking for exactly this kind of thread the other day
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op
Joined Nov 2022
