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Is this how you toot? 📯

I'm Lauren, Ph.D, former journal editor (PLOS Bio), podcast host (Bio Eats World), and sci comm specialist. I just started my own company (LR Bio) to help biotechs tell their science stories.

I'm always down to delve into the mysteries inherent in the vastness of biology!

#introduction #followfriday

Hi everyone--I'm Ami and I'm part of the #TwitterMigration. Still figuring this place out but it seems friendly, which is both delightful and disconcerting. I post about books, politics, repro rights, witches, Jewish stuff, and my dog. I'll try not to knock things over but I can't promise anything. #Introduction

Happy It's #flyday Friday! Why is 11/18 fly day? Because this is when good old w1118 was discovered! Hear it from the man himself, Gerry Rubin:

Said farewell to twitter this morning. Account closed. Posting and following #science and #cryoEM news here only.

Unbelievable, multiview-reconstruction & BigStitcher have finally lost their Imglib1-dependency! And all processing is now virtual thus scaling to larger volumes ... @herrsaalfeld

github.com/preibischlab/multiv
github.com/PreibischLab/BigSti

genetic model system bugs 

Happy Fly Day to all who celebrate!

#neuroscience #neurotheory

My group is recruiting Flatiron Research Fellows! 
Our interests include: theory development + data analysis with neural manifolds, and theory of neural networks.

Neuro interactions with Flatiron CCN, NYU Center for Neural Science, Machine Learning interactions with NYU Center for Data Science.

simonsfoundation.wd1.myworkday

Hi everyone. We’re #Co_Biologists, a not-for-profit #publisher dedicated to inspiring the #biology community:

- We publish five #journals: @Dev_journal @J_Cell_Sci @J_Exp_Biol @DMM_Journal & @BiologyOpen
- We facilitate scientific #meetings & provide #grants for #researchers
- We run three #community sites: @the_node @preLights @focalplane_jcs
- We are committed to #OpenAccess
- We have initiatives to support early-career researchers #ECRs

#Introduction #DevBio #CellScience #Disease #Science

#Introduction Part 2:
My lab invented the open-source software CellProfiler and the imaging assay Cell Painting and we now focus on using our machine learning and deep learning skills for image-based profiling, to accelerate drug discovery and functional genomics. Our research led to the founding of Recursion, a clinical-stage techbio powered largely by the information in cell images.

#CellProfiler #DrugDiscovery #TechBio #RXRX #MachineLearning #DeepLearning

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I recommend this article "DEI conversations: more than a box-ticking exercise" by @@felicitydavis2@twitter.com
nature.com/articles/s41580-022
I hope we can take her message to heart of *not* being incremental in our DEI work, just as we don't want to be incremental in our research. It reminded me of this post from @mekkaokereke fediscience.org/@mekkaokereke@
about finding the write framing for change that fits an organization's culture -- this seemed like a convincing framework for researchers!

#WomenInScience are recommended to 'not apologize a lot'.

A lot of issues would resolve themselves if #MenInScience apologized for their mistakes more.

Recognizing that you made a mistake, or that you don't know something, or behaved in a poor fashion and apologizing is not a problem. It tells me that you have the critical capability to introspect and understand what impact you have on others. It tells me that you care about doing #science right, that you want to learn.

#AI #ML

When a GABAergic neuron synapses onto the axon of a sensory neuron, what happens?

Turns out, in the proprioceptors of the locust leg (chordotonal somatosensory neurons), "All the available evidence indicates that the inputs that occur during walking are depolarizing, inhibitory, synaptic inputs."

Depolarizing, inhibitory. How's that possible? Depolarizing because of where the resting potential of the axon is (which is different than the dendrite's), and the particularities of the GABA receptor on the receiving axons. Inhibitory because the depolarization is subthreshold, reducing the membrane voltage potential and, therefore, reducing neurotransmitter release when a spike arrives.

What is this good for? Implementing an efference copy signal: "The rhythmic depolarization at different phases of the step cycle in different sensory neurons may represent a predictive action of the CNS when generating a motor pattern." That is, predicting when the proprioceptor will fire, and by how much, as a function of the self-induced motion. So this signal is subtracted in order to be able to measure (and react to appropriately) any unexpected signal (such as the leg skidding or hitting a rock).

Wolf and Burrows, 1995. "Proprioceptive sensory neurons of a locust leg receive rhythmic presynpatic inhibition during walking" jneurosci.org/content/15/8/562

Burrows and Matheson, 1994. "A presynaptic gain control mechanism among sensory neurons of a locust leg proprioceptor" jneurosci.org/content/14/1/272

#Social #bees, e.g., #Apis and #Bombus, have larger #foraging ranges than #solitary bees, because bigger bees have greater flight abilities, and also because bees from greater colonies need to travel further to avoid competition with their colony members.
bit.ly/3EHy7Hv

I've been sitting on this paper from @ScottishWaddell@twitter.com and @ManuPerisse@twitter.com because y'all know MB neuron names give me anxiety. But it's illustrated so well you don't need the names! Flies use both aversive and reward-coding DANs to judge relative value. doi.org/10.1016/j.cub.2022.08.

RS-FISH was just released as open access article in @naturemethods

RS-FISH is a user-friendly software for accurate spot detection that is applicable to smFISH experiments, spatial transcriptomics, and spatial genomics. The approach enables fast spot detection in even very large volumetric datasets.

github.com/PreibischLab/RS-FIS
github.com/PreibischLab/RS-FIS

nature.com/articles/s41592-022

#introduction I'm a scientist at the MRC Laboratory of Molecular Biology in Cambridge, UK. Our group works on developing new #microscopes and #instruments for #StructuralBiology, especially #CryoEM. All the problems we work on are biological, but often turn into physics and then engineering and computation before being solved. A diversity of ideas, people, expertise and talents are the key to making it happen.

Need a good laugh? 

Do you keep hearing about machine learning taking over the world "soon anytime now"?

This entry of mine from 2009 has been labelled, presumably automatically, as "mature content". I kind of see why–not quite an adversarial attack, but yes quite the failure of excessive generalization.

It's a most innocent photograph: that of my favourite lunch, back from when I was at INI Zurich: mozzarella with cherry tomatoes, olive oil, salt, and ... bread.

#Postdoc position to investigate cGAS-STING-dependent signaling in drosophila. A three-year postdoc position starting in spring 2023 with Jean-Luc Imler and 🐘krin_meignin@drosophila.social at IBMC in Strasbourg (France). #immunity #drosophila #virus

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