Apple pie @applepie@social.cleverlibre.org

Hi everyone👋 #preLights is a #preprint highlights service run by the biological #community and supported by #Co_Biologists allowing researchers to:

🔎 Sift through the growing volume of preprints.
💡 Highlight new thinking or new techniques across the biological sciences.
📝 Comment on preprints that are of particular interest.
👥 See comments and opinions of other researchers.

Toots from Reinier Prosée, the preLights community manager.

#Introduction #Biology #ECRs #Science #AcademicMastodon

MSA-free end-to-end antibody structure prediction.

https://www.biorxiv.org/content/10.1101/2022.11.10.515918v1

Happy #FluorescentFriday folks! Because everything seems a little dark on the otherside, we are sharing some color-tastic eye-popping pics to kick off the week-end.... #cilia #flagella #MicroscopeMagic #TubulinCode

Are grad students on here? Seems like it leans toward senior and mid career folks.

Q directed to grad students / postdocs who are checking this out:

What practices/behaviors would make this space useful for you?

How can senior folks best promote your work or interact w you here?

My sister didn't have a lot of #RStats training in undergrad so texts me questions about R-- happy to help, it's fun to be useful

But today she asked about putting significance indicators (brackets and stars) on R plots. I wasn't ready to admit I do that using photoshop, so I googled it and found a newer package to easily add them in ggplot2! So excited I had to share!

https://cran.r-project.org/web/packages/ggsignif/vignettes/intro.html

Computational Biologist - Virology (postdoc or equal) @RNA_Life

Join The Laboratory for RNA-based Lifeforms @ #UofT and discover Earth's #RNA viruses
#ComputationalBiology #Bioinformatics #Virology #CloudComputing

https://jobrxiv.org/job/university-of-toronto-27778-computational-biologist-virology-postdoc-or-equal/?feed_id=29520
#Science...
https://jobrxiv.org/job/university-of-toronto-27778-computational-biologist-virology-postdoc-or-equal/?feed_id=29520

Hi #devbio #devbiol Mastodon,

If you like sharing and discussing #preprints, you might like to know that Development publishes 'In preprints' articles.

Please do feel welcome to get in touch if you would be interested in writing an article on a preprint - or preprints - that interest you.

Learn more about this article type here: https://doi.org/10.1242/dev.200711

Supercool paper on #transposons in A. lyrata; suggests the use of TEs to increase heterozygosity during extreme inbreeding
https://www.nature.com/articles/s41467-022-34795-4

TEs are the best.

Also "0.6% of men in the UK Biobank lack a functional MAP3K15 gene without any apparent [health] issues"
'Exome Sequencing Study Identifies Potential Treatment Target for Diabetes' https://www.genomeweb.com/genetic-research/exome-sequencing-study-identifies-potential-treatment-target-diabetes?utm_source=addthis_shares#.Y3Y59ZUiRLE.twitter

Y’all, if you’re getting frustrated you’re not seeing the content you want to like news or intel you need on Mastodon, you really need to shift your thinking from algorithmic social media. Follower counts don’t matter much here. Likes do not matter to post reach. Without your interaction, you will just see a live FIFO firehose. Some quick fixes:

Hashtag your posts liberally and consistently, and follow key hashtags of interest to you. Hashtags matter a ton here to being seen.

Follow and also alert on accounts you always want to see content from.

Consider using the built in RSS feature for your feeds and for specific hashtags.

Consider switching to the more advanced UI in your preferences, so you can watch multiple filtered and unfiltered feeds. Or a different mobile app.

Use Fedifinder to follow all the accounts you followed on Twitter, and sync up your follow and block lists.

Avail yourself of the multiple public lists of hundreds of journalist accounts on Mastodon.

#mastodontips

Any recommendation for long read #RNA-seq #analysis #pipeline? #bioinformatics

I've been using #AnnotatedEquations in my recent papers. I think it really adds to the readability and understanding of the math.

Here are some examples. It uses #tikz in #latex.

Let me know if you like it. Happy for any feedback.

"The controlled expression of one cellular feature -- the cilium -- was likely critical during early animal evolution. Two key transcription factors, RFX and FoxJ1, coordinate ciliogenesis in animals but are absent from the genomes of most other ciliated eukaryotes, raising the question of how the transcriptional regulation of ciliogenesis has evolved."

#CellBiology #CIlia #evolution #Preprint

https://www.biorxiv.org/content/10.1101/2022.11.11.515474v1

Thrilled to share our lab's first paper in which we establish genome-wide CRISPR screening within a single mouse! We are so excited about the power of this platform to enable high-throughput genetic dissection of diverse phenomena within a living mammal.

https://www.cell.com/cell-genomics/fulltext/S2666-979X(22)00170-7

Managed to update a recycled talk for my unexpected 1pm #seminar during an incubation this morning and get two #nanopore library preps done and on the #GridION almost by 5pm this afternoon. I wish my average day was as productive.

Dorado v0.0.2 released!

- Faster basecalling
- 5mC calling with multi-GPU support
- Better performance on Apple M1 devices.

Stay tuned for a big release at NCM #nanoporeconf where I will be presenting BIG new Dorado features.

https://github.com/nanoporetech/dorado/releases/tag/v0.0.2