bioRxiv @biorxivpreprint@social.cleverlibre.org

RAD-TGTs: Measurement of cellular tensions via flow cytometry and DNA sequencing enabled by force-dependent rupture and delivery of DNA tension probes https://www.biorxiv.org/content/10.1101/2022.11.08.515662

Clinical PARP inhibitors allosterically induce PARP2 retention on DNA https://www.biorxiv.org/content/10.1101/2022.11.08.515634

What drives chorismate mutase to top performance? Insights from a combined in silico and in vitro study https://www.biorxiv.org/content/10.1101/2022.11.08.515563

Directed evolution of mesophilic HNA polymerases providing insight into DNA polymerase mechanisms https://www.biorxiv.org/content/10.1101/2022.11.08.515583

The genome of the brackish-water malaria vector Anopheles aquasalis https://www.biorxiv.org/content/10.1101/2022.11.08.515629

Shifted PAMs generate DNA overhangs and enhance SpCas9 post-catalytic complex dissociation https://www.biorxiv.org/content/10.1101/2022.11.08.515552

Analysis of alternative polyadenylation from long-read or short-read RNA-seq with LAPA https://www.biorxiv.org/content/10.1101/2022.11.08.515683

Nucleosome sensitivity distinguishes colon polyps based on their transformation status https://www.biorxiv.org/content/10.1101/2022.11.08.515478

Human Nucleolar Protein 7 (NOL7) is required for pre-rRNA transcription and pre-18S rRNA processing https://www.biorxiv.org/content/10.1101/2022.11.08.515626

Fasciola hepatica juveniles interact with the host fibrinolytic system as a potential early-stage invasion mechanism https://www.biorxiv.org/content/10.1101/2022.11.07.515559

ToDD: Topological Compound Fingerprinting in Computer-Aided Drug Discovery https://www.biorxiv.org/content/10.1101/2022.11.08.515685

An unbroken network of interactions connecting flagellin domains is required for motility in viscous environments https://www.biorxiv.org/content/10.1101/2022.11.07.515560

Flagellin modulates regulation of Clostridiodes difficile pathogenesis in the absence of motility https://www.biorxiv.org/content/10.1101/2022.11.08.515568

Application of Quasimetagenomics Methods to Define Microbial Diversity and Subtype Listeria monocytogenes in Dairy and Seafood Production Facilities https://www.biorxiv.org/content/10.1101/2022.11.07.515551

Shigella serotypes associated with carriage in humans establish persistent infection in zebrafish https://www.biorxiv.org/content/10.1101/2022.11.08.515620

Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system https://www.biorxiv.org/content/10.1101/2022.11.08.515452

The enzyme Rnf completes the pathway for forming propionate during fermentation in Prevotella https://www.biorxiv.org/content/10.1101/2022.11.08.515646

Ex vivo intestinal permeability assay (X-IPA) for tracking barrier function dynamics https://www.biorxiv.org/content/10.1101/2022.11.08.515584

Membrane-remodeling protein ESCRT-III homologs incarnate the evolution and morphogenesis of multicellular magnetotactic bacteria https://www.biorxiv.org/content/10.1101/2022.11.08.515611

Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted by metastasis https://www.biorxiv.org/content/10.1101/2022.11.08.513062