hkl @hkl@social.cleverlibre.org
Professor of Neuroscience (Johns Hopkins Univ.)
Research interests: cortical plasticity, cross-modal plasticity, synaptic plasticity, metaplasticity, vision loss, visual cortex, auditory cortex
ORCID: 0000-0002-5554-983X
Joined Nov 2022
@lakens Thanks for posting this! There is over-reliance on p-values for scientific publishing these days. Very refreshing to see this discussion.
hkl
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Now, for the first time, UCLA #scientists have attached nanoscale #biochemical #sensors, which are tuned to identify specific #neurotransmitters, to a soft, implantable #brain probe in order to continuously monitor these #chemicals in real time.
#Neuroscience #Psychiatry #Chemistry #Engineering #sflorg
https://www.sflorg.com/2022/12/ns12172201.html
@IvanMasl0v Pretty cool fireworks 
Now I'm super curious. What is it?
hkl
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#Optogenetic therapy for visual restoration https://www.mdpi.com/1422-0067/23/23/15041
hkl
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Do you hear what I see? How do early #blind individuals experience object motion? https://royalsocietypublishing.org/doi/10.1098/rstb.2021.0460 "#Blindness leads to cross-modal recruitment of the #visual motion area hMT+ for #auditory motion processing"; #crossmodal #neuroscience
@seeingwithsound Good points. I agree that nothing beats 1 to 1 support, if resources are available.
hkl
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I am especially excited about this piece I wrote for @pennNeuroKnow in collaboration with the International Autoimmune Encephalitis Society (IAES).
In response to patient and family questions, I attempted to synthesize how the brain heals from AE and why there's so much variability in the healing process.
@seeingwithsound Have you thought about using video game to train people. I was at a seminar where Daphne Maurer gave a talk describing her work that showed visual improvement in people with amblyopia. Her idea was that motivation is key for perceptual learning. Here's her publication if interested.
https://pubmed.ncbi.nlm.nih.gov/23193607/
hkl
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#OpenScience is encouraging the publication of null or negative results for it is the best way to avoid spending time, energy and money repeating unnecessary experiments. https://junanaguy.medium.com/the-unreasonable-effectiveness-of-shared-null-results-c51d0b09bcf5
@seeingwithsound
So what is the limiting step for this to move forward to more users? Is it difficulty in mastering its use or does it need more development to provide better sound information?
hkl
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Brain Stimulation Could Help Treat Alzheimer’s Disease
Deep brain stimulation at the intersection of two fiber bundles linked to memory formation appears to alleviate symptoms of Alzheimer’s disease.
#Neuroscience #Neurology #Neurotechnology #Brain
#NeurologicalDiseases #NeurodegenerativeDiseases
#Alzheimer #Dementia
#DeepBrainStimulation #DBS
@seeingwithsound Thanks! It seems the person has good success using the glasses.
hkl
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What’s a hypothesis?
“A hypothesis is not simply a guess about the result of an experiment. It is a proposed explanation that can predict the outcome of an experiment. A hypothesis has two components: (1) an explanation and (2) a prediction. A prediction simply isn’t useful on its own.” (Haroz, 2014)
Blog post: http://steveharoz.com/blog/2014/mysterious-origins-of-hypotheses-in-visualization-and-chi/
#MetaScience
#MetaResearch
#PsychMethods
#ReplicationCrisis
#PhilosophyOfScience
#PhilSci
#PhilScidon
hkl
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Entertaining article about why gatekeeping all of science with pre-publication peer review was a bad idea.
The rise and fall of peer review
https://open.substack.com/pub/experimentalhistory/p/the-rise-and-fall-of-peer-review?utm_source=direct&utm_campaign=post&utm_medium=web by Adam Mastroianni
hkl
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@seeingwithsound That makes sense! Thanks 
@seeingwithsound Thanks! I didn't know that. Doesn't bone conduction has a different frequency range as with airborne sounds? I remotely remember that it loses high frequency range. If so, does that pose a limit to what can be conveyed through the system?
hkl
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New preprint from the lab. Ji trained mice on an interactive auditory task in which they control the frequency of a tone with a wheel. Imaging showed that neurons in A1 encode sound, action, and errors. Thus, A1 not only encodes sensory driven activity but also represents the complex interplay between sensory inputs, expectations, and errors. So much more to discover!
https://www.biorxiv.org/content/10.1101/2022.12.12.520155v1
@seeingwithsound Topo-speech is an interesting concept to represent space. Look forward to the full article to learn more
One question I have with visual to auditory substitution is how it may interfere with normal environmental sound. There are a lot of cues from the environment that such vision-to-sound systems would be masking.
hkl
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The Topo-Speech sensory substitution system as a method of conveying spatial information to the blind and vision impaired https://www.frontiersin.org/articles/10.3389/fnhum.2022.1058093/abstract
Professor of Neuroscience (Johns Hopkins Univ.)
Research interests: cortical plasticity, cross-modal plasticity, synaptic plasticity, metaplasticity, vision loss, visual cortex, auditory cortex
ORCID: 0000-0002-5554-983X
Joined Nov 2022
