kwitschas @kwitschas@social.cleverlibre.org

How 'visual' is the visual cortex? The interactions between the visual cortex and other sensory, motivational and motor systems as enabling factors for visual perception https://royalsocietypublishing.org/doi/full/10.1098/rstb.2022.0336 "we propose that visual percepts are generated by a larger network—the extended visual system—spanning other sensory cortices, supramodal areas and frontal systems."

Assistant Professor positions call at Karolinska:
#sciencejobs

https://ki.varbi.com/en/what:job/jobID:640655/

Postdoctoral position available on Hsp70 and ALS

University of North Carolina at Charlotte

Postdoctoral position available on using structural proteomics to investigate the role of Hsp70 in Amyotrophic Lateral Sclerosis (ALS).

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-north-carolina-at-charlotte-27778-postdoctoral-posi...
https://jobrxiv.org/job/university-of-north-carolina-at-charlotte-27778-postdoctoral-position-available-on-hsp70-and-als/?feed_id=54767

Very proud of this paper that was led by a wonderful postdoc in my lab, Iva Lučić. My first paper without any channels, I think. #biophysics #enzymes #neuroscience #memory

CaMKII autophosphorylation can occur between holoenzymes without subunit exchange https://doi.org/10.7554/eLife.86090

Postdoctoral fellow in neurology, lipid biology and metabolomics

Harvard Medical School & Brigham & Women's Hospital

Come join us in #Boston as a #postdoctoral fellow studying #lipid metabolism in neurodegenerative disease to identify therapeutic targets.

See the full job description on jobRxiv: https://jobrxiv.org/job/harvard-medical-...
https://jobrxiv.org/job/harvard-medical-school-brigham-womens-hospital-27778-postdoctoral-fellow-in-neurology-lipid-biology-and-metabolomics/?feed_id=54071

STING is a channel?

'On the basis of structural analysis, we hypothesized that human STING is a proton channel. Indeed, we found that STING activation induced a pH increase in the Golgi and that STING reconstituted in liposomes enabled transmembrane proton transport.'

https://www.science.org/doi/10.1126/science.adf8974

Hahahahah. Holy shit.

So Zoom is irrevocably turning their entire network into a training data set: https://hackers.town/@devlogic/110843380784157782

EVERY "public service" company is now attempting to extract value. They're all going for it. They're gonna burn it all down to try and turn AI into a financial exit. Search engines, communication backbones, social networks, everybody.

Research Associate - Evrony Lab (NYU)

NYU - Evrony Lab

Come do exciting science at the Evrony Lab (NYU) as a Research Associate

See the full job description on jobRxiv: https://jobrxiv.org/job/nyu-evrony-lab-27778-research-associate-evrony-lab-nyu/?feed_id=53658

#ScienceJobs #hiring #research #genomics
New York City #UnitedStatesUS #ResearchTechnician
https://jobrxiv.org/job/nyu-evrony-lab-27778-research-associate-evrony-lab-nyu/?feed_id=53658

Fantastic postdoc opportunity with Joni Wallis at Berkeley https://neurojobs.sfn.org/job/36633/postdoctoral-position-in-neurophysiology/

A useful reminder from Adam Mastroianni:

“Everyone agrees that open-access scientific articles are great. What most people don’t know is that ‘open-access’ often means that the authors paid the journal to make their article freely available. As in, the journal was going to make money charging readers, but it charges the writers instead. And those writers are usually paying with federal grant money. So ‘open access’ is really ‘government scientific funding goes directly to for-profit publishers.’

How much money are we talking here? Sam Gershman, a neuroscientist at Harvard, estimates that it’s millions of dollars per week. Just as one data point, getting Nature to make The Illusion of Moral Decline open-access cost a jaw-dropping $12,000. This is truly one of the greatest scams of all time.”

🔗 https://www.experimental-history.com/p/how-many-people-has-dolly-parton

#OpenScience #OpenAccess

ChatGPT-like AI (LLMs) are coming to scientific search. Yesterday two big science databases, Scopus (Elsevier) & Dimensions (Digital Science), announced ChatGPT-based LLMs. Web of Science (Clarivate) plan similar. The concept is not like Meta's Galactica though -- more like Bing or Perplexity.
Here's my report in Nature: https://www.nature.com/articles/d41586-023-02470-3

It's that time of year!!

Time to help Skype a Scientist by telling every teacher, librarian, troop leader, etc you know that Fall 2023 enrollment is OPEN!

Sign up here http://bit.ly/EnrollFall2023

We rely on word of mouth to grow, so this action is critical for us!

I just found out alternative splicing is probably a massive lie and it's breaking my brain.

"Our results show that in genes with a median expression level, 92–98% of observed splice variants correspond to errors [not functional variants]." (Saudemont et al., 2017)

Almost all the variation we see in splicing patterns is probably just from the spliceosome being error-prone. WHAT?!

I guess this is another case of the cell not being a machine but rather a cobbled together sloppy mess, that still manages to self-organise. How insane.

https://sandwalk.blogspot.com/2022/08/splicing-errors-or-alternative-splicing.html

https://doi.org/10.1186/s13059-017-1344-6

Finding academic folks on Mastodon: a list of lists by @hendrikerz

https://github.com/nathanlesage/academics-on-mastodon

#AcademicMastodon @academicchatter

“This highly cited Science paper is riddled with problematic blot images,” it said. That anonymous 2015 observation helped spark a chain of events that led Stanford’s president, Marc Tessier-Lavigne, to announce his resignation this month.'

https://www.nytimes.com/2023/07/30/opinion/stanford-president-student-journalist.html

This may be my all time favorite meme. Bury me in it.

New posting! This one is a #HowTo guide on how NOT to start a research group in #academia - in other words, all the things that I wish I'd done differently or that I wish I'd been more aware of when I started back in 2015. I hope that helps anyone else out there taking their first steps in this direction! (And any comments/additions very welcome). 👇

https://totalinternalreflectionblog.com/2023/07/30/shutting-up-shop-a-short-guide-on-how-not-to-start-a-research-group/

"Here, using tunable collagen-coated hydrogels of physiological stiffness, we show that human primary monocytes undergo a dynamic local phase separation to form highly patterned multicellular multi-layered domains on soft matrix."
#Preprint

https://www.biorxiv.org/content/10.1101/2023.07.27.550819v2

This week, I went over to Bluesky and asked people who'd left Mastodon why they left, and lots of people told me. I grabbed the replies and crunched them and wrote up a summary. I think it's really interesting and often kind of wrenching.

https://erinkissane.com/mastodon-is-easy-and-fun-except-when-it-isnt

#meta

Emmert-Streib, F. Can ChatGPT understand genetics?. Eur J Hum Genet (2023). https://doi.org/10.1038/s41431-023-01419-4 #OpenAccess #OA #ChatGPT #AI #Artificialintelligence #Genetics #Science @science