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If you work with #scRNAseq, you should have a look at tidyseurat github.com/stemangiola/tidyseu

It creates an invisible layer that enables viewing the Seurat object as a tidyverse tibble, and provides Seurat-compatible dplyr, tidyr, ggplot & plotly functions

#rstats #Genomics

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use #linux & #opensource this year
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Compromised PyTorch-nightly dependency chain between December 25th and December 30th, 2022.

Steals all your SSH keys!

"If you installed PyTorch-nightly on Linux via pip between December 25, 2022 and December 30, 2022, please uninstall it and torchtriton immediately, and use the latest nightly binaries (newer than Dec 30th 2022)."

#infosec #machinelearning #deeplearning

pytorch.org/blog/compromised-n

news.ycombinator.com/item?id=3

It’s done! 365 days of recording the local temperature and weather in a knitted scarf.

I cannot keep this to myself. There is a website (radio.garden) where you can listen to radio stations all over the world for free. No log in. No email address. Nothing.

When the site loads, you are looking at the globe. Slide the little white circle over the green dots (each green dot is a radio station) until you find one you like.

I have been listening to this station in the Netherlands and it absolutely slaps. I have no idea what they're saying but the music is fantastic.

Happy to share our new article, which has been in the making for a veeery long time!

insight.jci.org/articles/view/

In this study we looked at the control of the entrance of in the

Ghrelin is a produced by the stomach, which induces hunger. In order to do so, ghrelin needs to enter the brain, to reach neurons in the arcuate nucleus of the , a region of the brain important for many responses.

Here, we explore the role of cells lining the capillaries (such as ) at the median eminence, which is on of the "doors" of the brain, where molecules from the periphery are allowed to get in.

We used a mouse model where pericytes can be electrically excited via to study the dynamics of ghrelin entrance in the brain. When we excited pericytes, there was a slow-down of blood flow at the median eminence, resulting in slower entrance of ghrelin, lower and delayed food intake in response to ghrelin injection.

This shows pericytes as a potential therapeutical target for metabolic diseases.

Use Mastodon 🐘 on desktop? I made a Chrome extension (works in Edge, Safari & Firefox coming soon!) to make following people, favoriting, bookmarking & boosting toots on remote instances easy as your home instance! (1-click)!

🙌 Appreciate the boosts! 🙌

🌐 Install Graze For Mastodon — chrome.google.com/webstore/det

🗨️ Suggestions or issues — graze.canny.io/

❓ Frequently Asked Questions — faqabout.me/iam/graze

#Mastodon #GrazeForMastodon #fediverse #programming #MastodonTips

Sister Mary Kenneth Keller was born #OTD in 1913. She worked with John G. Kemeny and Thomas E. Kurtz on the design and implementation of Beginner’s All Purpose Symbolic Instruction Code — BASIC — and was the first woman in the US to earn a PhD in Computer Science.

10 PRINT “HAPPY BIRTHDAY”
20 GOTO 10

How did I miss this conference?

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#NormConf is the tech conference about all the stuff that matters in data and machine learning, but doesn't get the spotlight.
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Topics include:

- How small can I get that Docker container?
- What's the simplest possible thing that might work, and why didn't you try that first?
- Data ethics: the non-sexy parts

The good thing: all videos are available 🤓

#NormIPS

normconf.com/

The thing about #depression is it can take away all joy in life.
Things you once loved, whether it's art, projects, cooking/food, etc. It can sap you of motivation, take the fun out of activities, and really make things generally more difficult.

These can also be indicators that you're depressed.

If you like the idea of using #RStats {targets} 📦 for reproducible data analysis, updating only things that need to be updated, and keeping yourself organized; but have struggled how to use it within a data analysis, I have a blog post that might help you.

In the post, I show how I work through an example lipidomics analysis using {targets}, that should be generally applicable to many, many data analyses, even non-omics.

Creating an Analysis With a targets Workflow

rmflight.github.io/posts/2022-

Twitter; abuse 

Shout out to the pro-science folks here and on twitter who admonished me for leaving and told me (1) I was letting down the cause and (2) by leaving I was playing politics instead of doing science.

No. A bully runs that house, and I'm walking out the door. You have no right to tell anyone to stay with an abuser and put up with threats to their own safety.

Unless you've weathered three years of death threats for your public health advocacy, keep it to yourself.

Hi, first toot! I'm a scientist and secular humanist. I love reading (fantasy and sci-fi but anything really), clouds, timekeeping, moose, the 80s, and classic rock music. Causes include the planet, human trafficking, and US blue wave 🌊

Tis the season to be marking

Falalalalaaaa la la la laaa

@mcaleerp and I collected together all our ideas for making feedback and engaging students in using that feedback to make some tools that we and others can use go make better and useful feedback, but also tools to help student to use that feedback.

Access our article here:
osotl.org/index.php/osotl/arti

#sotl #feedback #assessment #teaching

Is there any one familiar with analysis of ?

I'm having some bizarre issues when using to align them and I'm almost out of ideas of what to try next...

Here's an explanation of my issue

biostars.org/p/9546698/

Wow, this paper on #scRNAseq and differential expression methods is an eye opener. nature.com/articles/s41467-021

Nice overview of methods and relatively easy to understand explanation of what is wrong with certain, especially single-cell-specific, methods.

Of great help in my own scRNA-seq efforts. Should probably have read this earlier. Now, back to R I go. 😅

#statistics #rnaseq #limma #edgeR #DESeq2

As a blind individual, I have to say that #Caturday on #Mastodon is far far more enjoyable then at #Twitter, where the vast majority of cat photos are not described.

It is also been fascinating for me to hear descriptions written by those who sent the image, immediately followed by Apple image recognition’s attempts to describe the same image. Only rarely does that add anything to the ALT, & often directly contradicts it.

There is no auto magical solution to image description. It is something best done by a human, for only that human can explain the “why” of the image: the reason that image was chosen to speak so eloquently without words for those who can see it. ALT allows you to provide those words.

Pride in history can be detrimental to progress. It can make people delusional that they’re special relating to times they didn’t exist in. The reality of those times is often translated to them as one-sided stories where they imagine themselves to be the heroes. They get stuck.

"More than our rank".
This is an initiative that every university would do well to join, regardless of its ranking.
Indeed, each institution, for various reasons, many of which are its own, is worth much more than the rank assigned to it by a limited, indigent and ideologically connoted system of indicators.
inorms.net/more-than-our-rank/

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