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Tavo

Mutations in BCAT1 can produce Hypervalinemia and hyperleucine-isoleucinemia (HVLI) a condition with high levels of leucine and isoleucine in plasma. Generating headaches and memory impairment as well as metabolic acidosis.
malacards.org/card/hypervaline

Abnormal levels of branch chains amino acids in plasma have been found in COVID-19 patients.
ncbi.nlm.nih.gov/pmc/articles/

Treatments targeting BCAT1 have shown success in treating some of the post-acute sequelae symptoms. Gabapentin improves parosmia (altered perception of smells) after COVID-19 infection.
ncbi.nlm.nih.gov/pmc/articles/

Also, a case report has shown that gabapentin can be used to manage the tinnitus that resulted from the COVID-19 infection
sciencedirect.com/science/arti

Mutations in HDAC2 can produce Chronic obstructive pulmonary disease, a disease characterized by shortness of breath, wheezing, productive cough, and chest tightness.
malacards.org/card/pulmonary_d

Specific manipulation of HDAC2 by SARS Cov 2 is regulated by NSP5, this manipulation results in the downregulation of MHCII.
biorxiv.org/content/10.1101/20

SARS Cov 2 main protease can also cleave HDAC2 and reduce the interferon response.
jbc.org/article/S0021-9258(23)

ACE2 expression is regulated by different HDACs making them a target for COVID-19 treatment.
link.springer.com/content/pdf/

Panobinostat an HDAC2 inhibitor showed a decrease of viral entry on cell culture.
pubs.acs.org/doi/full/10.1021/

While Theophylline, another HDAC2 inhibitor has been used to treat several post-acute sequelae symptoms such as sinus bradycardia.
mdpi.com/2039-7283/11/2/47

Atrioventricular block.
heartrhythmcasereports.com/art

And the improvement of smell function over a randomized controlled trial.
jamanetwork.com/journals/jamao

PANK3 is a gene related to Neurodegeneration with Brain Iron Accumulation 1 and Woodhouse-Sakati Syndrome.
genecards.org/cgi-bin/carddisp

A target of PANK3 is Pantothenic acid or B5, and B5 offers a protective effect against COVID-19.
web.archive.org/web/2022111701

CHN1 is a gene related to Duane Retraction Syndrome 2 a condition with restricted horizontal eye movement.
malacards.org/card/duane_retra

Alterations in eye movement have been found as a post-acute of COVID-19.
ncbi.nlm.nih.gov/pmc/articles/

CHN1 plasma levels are correlated with inflammation and disease severity.
frontiersin.org/articles/10.33

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Tavo

SARS Cov 2 molecular mimicry
open.substack.com/pub/tavoglc/

0
Tavo boosted
Olver :neurodiversity:

🐓 🐖 🐇 🦎
#SARSCoV2 is not only found in wastewater. In Nigeria:
- "SARS-CoV-2 RNA was detected in almost all animal taxa and sampling locations except Oyo State."
- "The close human-animal interactions in these settings suggest ongoing reverse zoonosis"

I would add that the evolution of the virus in animals could be extremely dangerous if/when it infects humans again. There is no viral attenuation if the virus shuttles between different species.

Source:
ncbi.nlm.nih.gov/pmc/articles/

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Tavo

Do you like machine learning and would like to know how to apply it to biology? Then you might like my substack, currently focused on SARS COV2 due to the large and open datasets.

open.substack.com/pub/tavoglc/

0
Tavo boosted
Tixie Salander 💕

Repost from a poster seen in Melbourne

0
Tavo boosted
Tixie Salander 💕

Don’t forget to put a 🏳️‍🌈🏳️‍⚧️ somewhere in your software to easily prevent the fascists from using it 😋

1
Tavo boosted
Eniko Fox

Follow up: if you are limiting your participation in public indoor activities, are you considered or do you consider yourself immunocompromised?

896 people · May 30, 2023, 11:17
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Tavo boosted
Eniko Fox

Are you limiting your participation in indoor activities in public due to covid?

1738 people · May 30, 2023, 10:44
1+
Tavo

Metabolic alterations have been present in a series of genes, particularly involving diabetes. This suggests the highjacking of the insulin pathway from the virus, a component of this pathway is the PIK3C3 protein and its gene that is highly similar to the SARS Cov2 genome.
genecards.org/cgi-bin/carddisp

One of the diseases in which PIK3C3 has been involved is Neurodegeneration with Brain Iron Accumulation (NBIA) "disorder characterized by an abnormal accumulation of iron in the brain and progressive degeneration of the nervous system"
malacards.org/card/neurodegene

Iron accumulation has been suggested as a consequence of covid-19 by multiple studies.
alz-journals.onlinelibrary.wil

However, a direct measurement of iron accumulation in the brain remains to be assessed.
degruyter.com/document/doi/10.

PIK3C3 has been involved in the early steps of viral infection, particularly due to its involvement in endosome recycling.
sciencedirect.com/science/arti

Multiple studies have shown that PIK3 inhibitors inhibit SARS Cov2 viral replication in cell culture.
nature.com/articles/s41588-021

Exvivo analysis showed that inhibitors of PIK3 inhibited SARS Cov2 infection in ex vivo lung tissue cultures.
onlinelibrary.wiley.com/doi/ab

Clinically PIK3 inhibitors have shown decreased rates of COVID-19 in cancer patients.
jamanetwork.com/journals/jamao

Quercetin, another PIK3 inhibitor has also shown faster recovery rates when used with antiviral drugs in a clinical trial setting.
sciencedirect.com/science/arti

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Tavo

Solo espero tener el tiempo suficiente para terminar

0
Tavo

Another glycogen disease is Fanconi-Bickel Syndrome, among the main symptoms of this disease are myalgia, muscle cramp, and muscle rigidity. A gene associated with this disease is the SLC2A2 also known as GLUT2, a gene with high similarity to the SARSCov2 genome.
malacards.org/card/fanconi_bic

GLUT2 is also associated with type 2 diabetes, a condition with a rising number of cases and COVID-19 infection increases the chances of developing the disease.
thelancet.com/journals/landia/

Specific dysregulation of GLUT2 due to SARSCov2 infection results in altered expression patterns of GLUT2 in the pancreas, altering its function.
ncbi.nlm.nih.gov/pmc/articles/

It has also been suggested as a possible target for dysregulation by SARSCov2 infection in the intestine leading to diarrhea.
journals.physiology.org/doi/fu

Treatment targeting GLUT2 has not been used to treat SARSCov2 infection or long covid. However, the diabetes treatment metformin has been used to treat infection with successful results for patients with type 2 diabetes.
nature.com/articles/s41598-022

Regarding Long Covid metformin has been tested in a clinical trial with positive outcomes. However, the authors acknowledge the limitation of a lack of established criteria to define long covid.
ncbi.nlm.nih.gov/pmc/articles/

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Tavo boosted
Keith Dawson

Did you get Covid?

Please boost for greater reach.

11945 people · May 25, 2023, 22:19
1+
Tavo

Glycogen storage disease is also another exercise-intolerant disease. Particularly GSD III involves the liver, skeletal, and heart muscle, one cause of such disease is a mutation in the AGL gene.
ncbi.nlm.nih.gov/books/NBK2637

The AGL gene is a gene with high similarity to the SARS Cov2 genome and codifies for the AGL protein, a protein that debranches glycogen. Exercise intolerance in the scheme of GSD III has been suggested to be an energy deficiency.
pubmed.ncbi.nlm.nih.gov/235071

Direct involvement of AGL with SARSCov2 infection has not been found, however pharmacological treatments aiming at AGL have been found to inhibit viral replication.
academic.oup.com/glycob/articl

While Duvoglustat, another molecule that targets AGL only has been proposed as a treatment for viral infections.
pubs.acs.org/doi/full/10.1021/

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Tavo

Another common symptom of long covid is exercise intolerance. Although it is an uncommon symptom many other diseases generate exercise intolerance. One of those is Catecholaminergic polymorphic ventricular tachycardia (CPVT).
en.wikipedia.org/wiki/Catechol

CPVT causes an abnormal heart rate (arrhythmia) that can be fatal and is triggered by conditions of high excitement such as physical exercise. Mutations in Calmodulin 2, a calcium-handling protein, lead to CPVT.
pubmed.ncbi.nlm.nih.gov/255574

Calmodulin 2 is also associated with a series of cardiac diseases and Sudden Infant Death Syndrome. The main mechanism behind this is due to lower calcium affinity impairing calcium signaling.
journals.plos.org/plosone/arti

Calmodulin 2 is also another protein with high compositional similarity to SARSCov2 and also has a role inside the SARSCov2 infection pathway. Calmodulin interaction with ACE2 is important for the infection process.
link.springer.com/article/10.1

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Tavo

For some reason, I forgot to add the list of selected genes. This one contains the RefSeq Id

github.com/TavoGLC/SARSCov2Sol

And this one contains the gene description from the refseq file.

github.com/TavoGLC/SARSCov2Sol

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Tavo

Treating long covid is harder to assess, but there is at least one clinical trial assessing the efficacy with what appears to be promising results.
buffalohealthyliving.com/long-

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Tavo

Also, electronic health records showed a lower incidence of COVID-19 cases in subjects with therapeutic levels of lithium in their blood.
cambridge.org/core/journals/th

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1
Tavo

As well as a faster recovery rate, lowering the days with lymphopenia in a randomized clinical trial setting.
frontiersin.org/articles/10.33

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Tavo

Pharmacological interventions targeting CLOCK have also been successful in COVID-19 treatment. Lithium an inducer of clock gene expression has shown inhibitory effects of SARS Cov2 replication at the preclinical level.
sciencedirect.com/science/arti

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Tavo

And either pharmacological or genetic targeting of BMAL1 reduces SARSCov2 replication.

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