"Older vaccines use the postfusion, or Post-F, version of the protein, whereas new vaccines employ a prefusion stabilized, or Pre-F, immunogen. Here, Chang and Phung et al. directly compared immune responses elicited by a Post-F vaccine, MEDI7510, and a Pre-F vaccine, DS-Cav1. The authors found that DS-Cav1 elicited antibodies that more potently neutralized RSV A and B than MEDI7510. This enhanced response was mediated by the presence of antibodies that could bind sites on the F protein that were only present in the Pre-F state."
#RSV #RespiratorySyncytialVirus #Immunology #Vaccine
https://www.science.org/doi/abs/10.1126/scitranslmed.ade0424
> One of the central problems in fluid dynamics is to figure out if the [Euler] equations ever fail, outputting nonsensical values that render them unable to predict a fluid’s future states.
> Mathematicians have long suspected that there exist initial conditions that cause the equations to break down. But they haven’t been able to prove it.
> In a preprint posted online last month, a pair of mathematicians has shown that a particular version of the Euler equations does indeed sometimes fail.
...
> Perhaps in some situations, the equations will proceed as expected, producing precise values for the state of the fluid at any given moment, only for one of those values to suddenly skyrocket to infinity. At that point, the Euler equations are said to give rise to a “singularity” — or, more dramatically, to “blow up.”
> Once they hit that singularity, the equations will no longer be able to compute the fluid’s flow.
...
Computer Proof ‘Blows Up’ Centuries-Old Fluid Equations
https://www.quantamagazine.org/computer-helps-prove-long-sought-fluid-equation-singularity-20221116/
Very important and interesting work, if you're a mathematician, a physicist or an engineer that has ever 'crashed' with Euler/Navier-Stokes equations.
#math #physics #fluids #euler #navierstokes #equations #singularities
Omicron BA.5 infects human brain organoids and is neuroinvasive and lethal in K18-hACE2 mice https://www.biorxiv.org/content/10.1101/2022.12.22.521696v1?med=mas
He talked about electric cars. I don't know anything about cars, so when people said he was a genius I figured he must be a genius.
Then he talked about rockets. I don't know anything about rockets, so when people said he was a genius I figured he must be a genius.
Now he talks about software. I happen to know a lot about software and Elon Musk is saying the stupidest shit anyone's ever said, so when people say he's a genius I figured I should stay the hell away from his cars and rockets.
My spreadsheet of #COVID19 studies showing longer-term damage to the body has grown to 100 studies. Here's a link and a thread of some of the most interesting. The conclusion is that COVID can attack many parts of the body, remain present in the body, increase risks of serious cardiovascular, brain, lung and immune system disorders, and increase risk of death and disability. Stop taking it so lightly!
https://docs.google.com/spreadsheets/d/12VbMkvqUF9eSggJsdsFEjKs5x0ABxQJi5tvfzJIDd3U/edit?usp=sharing
I just published The almost complete guide for COVID-19: susceptibility and adaptation.
#COVID #COVID19 #CovidIsNotOver
People, please start using CamelCase to break apart words in #HashTags.
It makes it easier to read and more #accessible. Single words are OK to keep lowercase, unless they are proper nouns 😉
As an instance moderator, it makes it easier to review of you're a #MastoAdmin.
#Mastodon #HashTag #accessibilty
Please #boost this for visibility and to help improve the lives of many people.
Read this well written article on #Medium. Although the author explores how tech #journalism struggles with #Mastodon and how to describe it, he also touches upon another subject which I find striking: a key difference between Mastodon and #Twitter is not the #technology itself but the #values upon which both are built.
In 2023, we should make it a goal to help each other with our side hustles so we can make them our main hustles and we can all quit our jobs and break capitalism. How ‘bout it? Are we in? Tell me about your side hustle! #BusinessOnMastadon #SideHustle
Much of the T cell aging happens in convalescence. You see continued cell turnover, aging, and activation 100 days out
The above paper needs to follow up again at 100 days https://twitter.com/fitterhappieraj/status/1343583886723477507
I like to know stuff