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Renshaw01

Meet 10 Women in Science Who Changed the World

Great article in the March Discover magazine. The 10 women mentioned in the article are:
1. Ada Lovelace, Mathematician
2. Marie Curie, Physicist and Chemist
3. Janaki Ammal, Botanist
4. Chien-Shiung Wu, Physicist
5. Katherine Johnson, Mathematician
6. Rosalind Franklin, Chemist
7. Vera Rubin, Astronomer
8. Gladys West, Mathematician
9. Flossie Wong-Staal, Virologist and Molecular Biologist
10. Jennifer Doudna, Biochemist

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Tavo boosted
nathan@fosstodon:~$:idle:

Sounds like Laura Loomer has long Covid

#USPol #Politics #LauraLoomer #GOP #AltRight #RightWing #COVID #LongCOVID

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Tavo

Tired of all those COVID variants? get ahead of the game, and predict them yourself with JAX.
github.com/TavoGLC/SARSCov2Sol

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Tavo boosted
Simon Willison

Being able to pipe code to an LLM in the terminal is really fun

`symbex Request | llm --system 'add type hints to this'`

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Tavo

PPP1R12A is a gene involved in the regulation of microvilli in nasal epithelial cells. This pathway has been suggested as a target for SARS Cov 2 infection. .
sciencedirect.com/science/arti

Mutations in PPP1R12A can lead to a condition known as Coronary Artery Vasospasm, a condition related to angina pectoris and orthostatic intolerance. .
malacards.org/card/coronary_ar

Cases of coronary vasospasms have been reported in COVID-19 patients but in low numbers.
sciencedirect.com/science/arti

C9orf72 is a gene related to Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis a neurodegenerative disease. Patients with mutations on C9orf72 have a propensity toward psychosis or hallucinations.
malacards.org/card/frontotempo

Specific mutations in C9orf72 have been found to influence SARS Cov 2 infection and perhaps drive it toward a more pathogenic phenotype.
mdpi.com/1422-0067/22/13/6991

Mutations in TRNT1 can lead to Sideroblastic Anemia with B-Cell Immunodeficiency, Periodic Fevers, and Developmental Delay.
malacards.org/card/sideroblast

Mutations in TRNT1 could also be used as a risk factor for COVID-19. A case report study shows recurrent infections in patients with such mutations.
bmcinfectdis.biomedcentral.com

RORA is a gene related to Intellectual Developmental Disorder with or Without Epilepsy or Cerebellar Ataxia and Autism.
malacards.org/card/intellectua

RORA SNPs have also been found to be differentially expressed in different COVID-19 phenotypes. frontiersin.org/articles/10.33

Also, RORA is differentially expressed in heart failure among other genes. .
onlinelibrary.wiley.com/doi/fu

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Tavo boosted
Infectious Disease Tracker

Florida 🇺🇸 reports its first known case of chronic wasting disease (CWD) in a white-tailed deer in Holmes County.

CWD is a prion disease that affects deer, elk, reindeer, sika deer and moose. It has been found in some areas of North America, Norway and South Korea.

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Tavo boosted
Infectious Disease Tracker

⚠️ BREAKING:

Peru's 🇵🇪 health minister resigns as dengue fever case count surpasses 146,000 with 248 deaths in the country's largest dengue outbreak ever.

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Tavo

ADAM10 is a gene related to the neurodegenerative Alzheimer's disease.
malacards.org/card/alzheimer_d

Regarding SARS Cov2 infection ADAM10 mediates the priming of the spike protein and lung cell fusion.
embopress.org/doi/full/10.1525

ADAM10 inhibition reduces the entry of viral particles in cell culture.
journals.asm.org/doi/full/10.1

ADAM10 inhibition by Disulfiram has shown positive effects, as it inhibits the interaction between ACE2 and the spike protein in cell culture.
ncbi.nlm.nih.gov/pmc/articles/

While patients treated with Disulfram for alcohol user disorder showed a reduced risk for COVID-19.
ncbi.nlm.nih.gov/pmc/articles/

PDE4D is a gene related to Acrodysostosis 2 with or Without Hormone Resistance a condition with endocrine abnormalities and in females irregular menses.
malacards.org/card/acrodysosto

Although there's no information linking PDE4D and some SARS Cov 2 components, targeting it has been successful.

Tanimilast regulates the immune activation derived from SARS Cov 2 ssRNA. .
frontiersin.org/articles/10.33

While Dyphylline showed antiviral activity in cell culture, its effect is attributed to an off-target effect.
future-science.com/doi/full/10

CAMK4 is a gene related to autism and Cerebral hypoxia disease. A disease characterized by "Having a hard time paying attention * Poor judgment and decision making * Memory loss * Having a hard time controlling movement"
malacards.org/card/cerebral_hy

Clinical data shows elevated levels of CAMK4 in the kidneys of COVID-19
patients.
sciencedirect.com/science/arti

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Tavo boosted
Julie Webgirl - Just Your Luck

"Basic antibiotics have been in short supply in the US since October, when rising rates of respiratory infections led to increased demand for amoxicillin..."

Gee, I wonder why.

Rising rates of respiratory infections.

How odd.

#CovidIsNotOver #LongCovid #Covid

Pfizer Sees Antibiotic Supply Running Out as Shortage Worsens

bloomberg.com/news/articles/20

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Tavo boosted
Infectious Disease Tracker

Dengue fever cases tripled in Cambodia 🇰🇭 compared to the same time period last year.

3,439 cases have been reported in the country so far in 2023.

1
Tavo

INPP4B is differentially expressed in COVID-19 patients. Particularly had a negative correlation with disease severity.
sciencedirect.com/science/arti

DSC2 is a gene related to Arrhythmogenic right ventricular cardiomyopathy. A disease characterized by the breakdown of the myocardium and an increased risk of sudden death.
medlineplus.gov/genetics/condi

SARS Cov 2 infected cardiomyocytes with mutations in the DSC2 gene showed an increased viral load in cell culture.
jacc.org/doi/full/10.1016/S073

LAMP2 is a gene related to Left Ventricular Noncompaction, this disease is characterized by impaired cardiac development. Some of the symptoms of this disease are blood clots, shortness of breath, exercise intolerance, and sudden death.
malacards.org/card/left_ventri

LAMP2 also has a role during SARS Cov 2 infection, as a specific spike mutation accumulates in LAMP2-positive membranes.
ncbi.nlm.nih.gov/pmc/articles/

Furthermore, LAMP2 interacts with the 5' end of the SARS Cov 2 genome regulating the amount of viral RNA inside the infected cell.
journals.asm.org/doi/full/10.1

High expression of AGPAT5 in the livers of COVID-19 patients has been found.
nature.com/articles/s41392-020

TLR3 mutations are related to immunodeficiency that increases the susceptibility to herpes simplex virus (HSV), varicella-zoster virus (VZV), influenza A virus (IAV), hantavirus, and possibly respiratory syncytial virus (RSV).
malacards.org/card/immunodefic

Also, mutations in TLR3 are markers of COVID-19 disease severity in males.
tandfonline.com/doi/full/10.10

TLR3 induces the innate immune response against the SARS-Cov2 infection.
mdpi.com/1999-4915/14/2/189

A case report of interferon therapy in patients with TLR3 mutations shows that interferon therapy could be beneficial to patients that present such mutations.
link.springer.com/article/10.1

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Tavo

Mutations in BCAT1 can produce Hypervalinemia and hyperleucine-isoleucinemia (HVLI) a condition with high levels of leucine and isoleucine in plasma. Generating headaches and memory impairment as well as metabolic acidosis.
malacards.org/card/hypervaline

Abnormal levels of branch chains amino acids in plasma have been found in COVID-19 patients.
ncbi.nlm.nih.gov/pmc/articles/

Treatments targeting BCAT1 have shown success in treating some of the post-acute sequelae symptoms. Gabapentin improves parosmia (altered perception of smells) after COVID-19 infection.
ncbi.nlm.nih.gov/pmc/articles/

Also, a case report has shown that gabapentin can be used to manage the tinnitus that resulted from the COVID-19 infection
sciencedirect.com/science/arti

Mutations in HDAC2 can produce Chronic obstructive pulmonary disease, a disease characterized by shortness of breath, wheezing, productive cough, and chest tightness.
malacards.org/card/pulmonary_d

Specific manipulation of HDAC2 by SARS Cov 2 is regulated by NSP5, this manipulation results in the downregulation of MHCII.
biorxiv.org/content/10.1101/20

SARS Cov 2 main protease can also cleave HDAC2 and reduce the interferon response.
jbc.org/article/S0021-9258(23)

ACE2 expression is regulated by different HDACs making them a target for COVID-19 treatment.
link.springer.com/content/pdf/

Panobinostat an HDAC2 inhibitor showed a decrease of viral entry on cell culture.
pubs.acs.org/doi/full/10.1021/

While Theophylline, another HDAC2 inhibitor has been used to treat several post-acute sequelae symptoms such as sinus bradycardia.
mdpi.com/2039-7283/11/2/47

Atrioventricular block.
heartrhythmcasereports.com/art

And the improvement of smell function over a randomized controlled trial.
jamanetwork.com/journals/jamao

PANK3 is a gene related to Neurodegeneration with Brain Iron Accumulation 1 and Woodhouse-Sakati Syndrome.
genecards.org/cgi-bin/carddisp

A target of PANK3 is Pantothenic acid or B5, and B5 offers a protective effect against COVID-19.
web.archive.org/web/2022111701

CHN1 is a gene related to Duane Retraction Syndrome 2 a condition with restricted horizontal eye movement.
malacards.org/card/duane_retra

Alterations in eye movement have been found as a post-acute of COVID-19.
ncbi.nlm.nih.gov/pmc/articles/

CHN1 plasma levels are correlated with inflammation and disease severity.
frontiersin.org/articles/10.33

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Tavo

SARS Cov 2 molecular mimicry
open.substack.com/pub/tavoglc/

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Tavo boosted
Olver :neurodiversity:

🐓 🐖 🐇 🦎
#SARSCoV2 is not only found in wastewater. In Nigeria:
- "SARS-CoV-2 RNA was detected in almost all animal taxa and sampling locations except Oyo State."
- "The close human-animal interactions in these settings suggest ongoing reverse zoonosis"

I would add that the evolution of the virus in animals could be extremely dangerous if/when it infects humans again. There is no viral attenuation if the virus shuttles between different species.

Source:
ncbi.nlm.nih.gov/pmc/articles/

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Tavo

Do you like machine learning and would like to know how to apply it to biology? Then you might like my substack, currently focused on SARS COV2 due to the large and open datasets.

open.substack.com/pub/tavoglc/

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Tixie Salander 💕

Repost from a poster seen in Melbourne

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Tavo boosted
Tixie Salander 💕

Don’t forget to put a 🏳️‍🌈🏳️‍⚧️ somewhere in your software to easily prevent the fascists from using it 😋

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Tavo boosted
Eniko Fox

Follow up: if you are limiting your participation in public indoor activities, are you considered or do you consider yourself immunocompromised?

896 people · May 30, 2023, 11:17
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Tavo boosted
Eniko Fox

Are you limiting your participation in indoor activities in public due to covid?

1738 people · May 30, 2023, 10:44
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Tavo

Metabolic alterations have been present in a series of genes, particularly involving diabetes. This suggests the highjacking of the insulin pathway from the virus, a component of this pathway is the PIK3C3 protein and its gene that is highly similar to the SARS Cov2 genome.
genecards.org/cgi-bin/carddisp

One of the diseases in which PIK3C3 has been involved is Neurodegeneration with Brain Iron Accumulation (NBIA) "disorder characterized by an abnormal accumulation of iron in the brain and progressive degeneration of the nervous system"
malacards.org/card/neurodegene

Iron accumulation has been suggested as a consequence of covid-19 by multiple studies.
alz-journals.onlinelibrary.wil

However, a direct measurement of iron accumulation in the brain remains to be assessed.
degruyter.com/document/doi/10.

PIK3C3 has been involved in the early steps of viral infection, particularly due to its involvement in endosome recycling.
sciencedirect.com/science/arti

Multiple studies have shown that PIK3 inhibitors inhibit SARS Cov2 viral replication in cell culture.
nature.com/articles/s41588-021

Exvivo analysis showed that inhibitors of PIK3 inhibited SARS Cov2 infection in ex vivo lung tissue cultures.
onlinelibrary.wiley.com/doi/ab

Clinically PIK3 inhibitors have shown decreased rates of COVID-19 in cancer patients.
jamanetwork.com/journals/jamao

Quercetin, another PIK3 inhibitor has also shown faster recovery rates when used with antiviral drugs in a clinical trial setting.
sciencedirect.com/science/arti

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