This week, my lab recently published, and its my first co-authorship on a paper! 🎉

Our lab developed a high-throughput plasmid-based recombination assay, SARP-seq, to investigate RAG1/2's recombination of thousands of different DNA motifs.

The RAG1/2 recombinase facilitates the diverse antigen binding repertoire for the adaptive immune system, but can also aberrantly cause genomic instability.

Walker Hoolehan, Justin C Harris, Jennifer N Byrum, Destiny A Simpson, Karla K Rodgers, An updated definition of V(D)J recombination signal sequences revealed by high-throughput recombination assays, Nucleic Acids Research, 2022;, gkac1038, https://doi.org/10.1093/nar/gkac1038