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"Madi et al. report the surprising finding that human and murine FOXP3+ Tregs are a physiological relevant source of Interleukin-15, a homeostatic cytokine that promotes antigen-independent maintenance of CD8+ memory T-cells. In mice that lack IL-15 selectively in FOXP3+Tregs the authors show that the composition of the CD8+ T-cell memory pool is altered in the absence of Treg-derived IL-15, since a subset of terminally effector memory cells is drastically reduced."
https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.202250238
@cyrilpedia wow, that's really interesting. Makes me think a lot about the cytokine interdependent circuitry of IL2 projects by Adrian Liston and team. On my to-read list!