'An important aspect of this study is that we inferred the fitness landscape based on antibiotic resistance profiles and not genotypes. Although previous studies have focused on constructing fitness landscapes based on mutations for a few genes [4,6], because the number of possible genotype changes (e.g., nucleotide changes) associated with antibiotic resistance evolution is immense [32], empirical fitness landscapes based on genotypes were not capable of predicting/controlling evolution.'

#Evolution #EvolutionaryBiology #antibioticresistance #FitnessLandscape @PLOSBiology

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001920#sec008