"Here, we show that cGAMP delivery by intratumoral injection of virus-like particles (cGAMP-VLP) led to differentiation of circulating tumor-specific T cells, decreased tumor regulatory T cells (Tregs), and antitumoral responses that synergized with PD1 blockade."

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https://www.science.org/doi/10.1126/sciimmunol.abn6612#.Y8G4gZis1IU.twitter