"The strong dependence on T cells in MS animal models (experimental autoimmune encephalomyelitis, EAE) and the absence of antibodies in MS have long driven the assumption of MS being orchestrated by T helper cells (12), making those the most plausible therapeutic targets. But anti-CD20 therapies have been a game changer in the MS field."

#Immunology #MultipleSclerosis #MonoclonalAntibody #Autoimmunity

https://www.pnas.org/doi/10.1073/pnas.2221544120