It represents an incredible advance, but the reality of cancer immunotherapy continues to be that for most patients and tumor types it will not provide the hoped-for response. Identifying predictive biomarkers is one key to improving outcomes.

"This study reveals dynamic cellular changes occurring during effective ICT and the role of a set of biomarkers connected to the cytotoxic potential of CD8+ T cells, which are instrumental in tumor immunity and could be used to assess the level of immunotherapy efficiency."

#immunotherapy #immunology

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(23)00031-9