This is pretty cool:

'Here, we link PIEZO-mediated mechanotransduction to NLRP3 inflammasome activation. Yoda1, a PIEZO1 agonist, dramatically lowers the threshold for NLRP3 inflammasome activation. PIEZO-mediated stiffness-sensing increases NLRP3-dependent inflammatory responses. Activation of PIEZO1 triggers calcium influx, which activates KCNN4, a calcium-activated potassium channel, to evoke potassium efflux promoting NLRP3 inflammasome activation.'

https://www.biorxiv.org/content/10.1101/2023.03.08.531717v1