"Here we show that heme strongly alters macrophage functional response to AC damage by exacerbating immune cell recruitment and impairing cell efferocytic capacity. In SCD, heme-driven excessive leukocyte influx and defective efferocytosis contribute to exacerbated tissue damage and sustained inflammation."

https://ashpublications.org/blood/article-abstract/doi/10.1182/blood.2022018026/495064/Macrophage-metabolic-rewiring-improves-heme?redirectedFrom=fulltext