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'It is hoped that a spatially resolved picture of protein expression, posttranslational protein modifications, cell phenotypes, and communities of cell phenotypes will not only advance our understanding of tumor evolution (3) but also guide patient treatment response prediction modeling and the development of novel cancer therapeutics targeting the TME, such as bispecific T-cell engagers, immune-checkpoint inhibitors (ICI), and chimeric antigen receptor (CAR) T cells.'
