"These differences in expression necessarily limit the usefulness of these systems in identifying and understanding the more subtle roles played by ACE2 in the development and resolution of COVID-19. To overcome these limitations, we have developed two mouse lines in which the ACE2 locus has been humanized by syntenic replacement."

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https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011168