'We reveal that tonic IFN-I expression characterizes osteoclast precursors prior to receptor activator of NF-kappaB ligand (RANKL) exposure and that many tonic ISGs are repressed by RANKL signaling. In addition, the ISG response to RANKL is complex and multifaceted.'

https://www.pnas.org/doi/10.1073/pnas.2210409120