Our lab has started a weekly journal club covering classic papers in immunology. First up, Mosmann and Coffman use murine CD4+ T cell clones and establish the Th1/Th2 paradigm. Journal of Immunology in 1986.
"The derivation of two distinct types of Th cell clones raises the question of the total diversity of T cell phenotypes."
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@Rahimilab As the Sicilian saying goes, never build generalizations about immune physiology from data obtained from a single inbred mouse strain.
