Molecular atlas for Crohn's disease & ulcerative colitis in patients receiving anti-TNF.
'We describe a therapeutic atlas for Crohn's disease (CD) and ulcerative colitis (UC) following anti-tumour necrosis factor (TNF) therapy. We generated ~1 million single-cell transcriptomes, organised into 109 cell states, from 216 gut biopsies from 38 patients and three controls, revealing disease- and therapy-specific differences.'
#Preprint #IBD #ulcerativecolitis #crohnsdisease #immunology #TNF #immunotherapy #mucosalimmunology
@cyrilpedia thank you very much for sharing this - I was looking for exactly something like it - do you by any chance know (from memory) similar single cell data for other in vivo cytokine inhibition?
@cyrilpedia thank you 🙏