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'Tuberculosis (TB) is a heterogenous disease in humans with individuals exhibiting a wide range of susceptibility. This heterogeneity is not captured by standard laboratory mouse lines. We used a new collection of 19 wild-derived inbred mouse lines collected from diverse geographic sites to identify novel phenotypes during Mycobacterium tuberculosis (Mtb) infection.'
#Preprint #Tuberculosis #Immunology #HostPathogen #InfectiousDisease
@gpollara Absolutely - but this should be taken into account together with 'rewinding' the microbiome studies et al to reconsider what are real, species/evolutionary differences between model organisms and humans and what are artefacts of hyper clean inbred strains
@cyrilpedia yeah, v good point!
@cyrilpedia
Notwithstanding the caveats of mouse #TB models, that looks worth a read especially as it embraces heterogeneity of responses and outcomes.
Also, a new hashtag i should use more often! 😉 #hostpathogen
#preprint #tuberculosis #immunology #infectiousdisease