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'In some cases, GWAS results have highlighted previously underappreciated mechanisms contributing to pathogenesis. For example, genetic variants associated with AD risk are enriched in genes and enhancers (regions in the genome that control gene expression) acting in myeloid cells, likely microglia. This indicated the important role of innate immune cells in AD. Therefore, the enrichment of risk variants in specific biological pathways can deepen our mechanistic understanding of neurodegenerative diseases and may even point to new therapeutic targets.'
