"Although RBP-J is recognized as a key inhibitor of TNF-mediated osteoclastogenesis, the precise mechanisms that restrain TNF-induced differentiation of macrophages into osteoclasts are not fully elucidated. In this study, we identified that the Notch ligand Jagged1 is a previously unrecognized RBP-J target."

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2300317/265946/Jagged1-Acts-as-an-RBP-J-Target-and-Feedback?redirectedFrom=fulltext