'A study published in 2020, which drew together multiple pieces of research to track the health of almost 50,000 over-65s, showed the incidence rate of new cases of dementia in Europe and North America had dropped 13 per cent per decade over the past 25 years — a decline that was consistent across all the studies.'
https://www.ft.com/content/184f6e81-d9ce-4a14-84f0-5190ea36e798
@tg9541 There are vague references to a 2020 study then this "Grodstein’s study, published earlier this year, made a notable discovery. While signs of vascular disease in the brain appeared to have decreased over time, the extent of the distinctive markers of Alzheimer’s in the brain stayed the same. This led the team to hypothesise that “any decrease in clinical Alzheimer’s dementia might be due in part to better cardiovascular health and in part to increased resilience to [the causes of] Alzheimer’s”, such as amyloid plaque, rather than to a decrease in Alzheimer’s pathology itself." which I think refers to this
https://jamanetwork.com/journals/jamaneurology/article-abstract/2801809
Thanks for sharing this! The focus of Grodstein's study appears to be AD, not dementia at large. From what I read about neurodegenerative diseases (e.g., die-off of specific populations of neurons) age matters. Here, better resilience might have a similar effect.
Effects reducing resilience may include factors like infections in other parts of the body (e.g., observations regarding microglia). Arteriosclerosis definitively matters.
@cyrilpedia Sounds interesting but there is a paywall. Do you have any hints on researchers or publications?