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"How exactly the drug prevents major cardiac events isn’t fully understood. Some of the effects can likely be chalked up to weight loss itself, which is associated with improvements in metrics that influence heart health, such as blood pressure, Yang said. But mechanisms independent of weight loss may also be at work. In the trial, lower rates of cardiovascular events began showing up before participants lost weight. One explanation is the drug’s impact on inflammation, which is associated with heart disease: C-reactive protein, a rough proxy for inflammation, dropped by nearly 40 percent in study participants."
https://www.theatlantic.com/health/archive/2023/11/ozempic-wegovy-obesity-drugs-benefits/676011/
@cyrilpedia
CRP fixes C1. Think of all the C3a and C5a that--potentially--never get liberated from C3 and C5 as a downstream consequence of that reduction in CRP. That's going to translate to a huge reduction in inflammation in and of itself. C5a is terrible for the heart, too.