"Interestingly, residual Omenn Syndrome lymphocytes display characteristics proper of embryonic lymphocytes that emerge before, and independently from, hematopoietic stem cells (HSCs). This prompted us to hypothesize whether Omenn Syndrome autoreactive T-cells are generated in the embryo independently from HSCs."
#Immunology #autoimmunity #OmennSyndrome #Preprint

https://www.biorxiv.org/content/10.1101/2023.11.24.568475v1