"We sought to utilize a pathogenic human JAK1 GoF variant to probe the precise tissue-intrinsic mechanisms by which JAK1 signaling orchestrates various allergic pathologies. To do this, we generated a mouse line in which the endogenous murine Jak1 gene was replaced with a human JAK1 GoF mutation (JAK1GoF mice) that was reported in 2017."
#Immunology

https://www.sciencedirect.com/science/article/pii/S0092867423013132