'Neuroscientist Anita Lüthi would like to see future studies elucidate how the PV neurons decrease brain connectivity without shutting it down completely. “Sleep is not a coma; we are not totally knocked out,” says the University of Lausanne-based researcher. Perhaps there’s a parallel system that keeps some basal connectivity intact, she hypothesizes. Dan says the work is also getting a lot of attention from anesthesiologists, who are interested in knowing how the brain’s response to different forms of anesthesia compares to its response to sleep.'

https://www.pnas.org/post/journal-club/mouse-study-sheds-light-brain-powers-down