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"The idea that misfolded beta-amyloid might be a prion-like disease has also been around for a long time, because it makes a lot of sense. Indeed, histopathology of patients who died from transmitted CJD has already shown (in several studies) the presence of aggregated beta-amyloid protein, with the implication that this could have been transmitted as well. There have been also reports for over ten years that injection of human Alzheimer's brain proteins into mice leads to AD-like pathology in mouse brains. In 2018, the same authors of this new paper showed that archived samples of toxic cadaveric growth hormone did indeed contain substantial amounts of soluble beta-amyloid, and that injected thse into mice caused such pathology as well. Putting these and other lines of evidence together, this newest paper fits a puzzle piece right where you'd expect one to go. It shows that some of the growth-hormone-treated patients did indeed go on to develop 's, as feared."

science.org/content/blog-post/

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