"Older vaccines use the postfusion, or Post-F, version of the protein, whereas new vaccines employ a prefusion stabilized, or Pre-F, immunogen. Here, Chang and Phung et al. directly compared immune responses elicited by a Post-F vaccine, MEDI7510, and a Pre-F vaccine, DS-Cav1. The authors found that DS-Cav1 elicited antibodies that more potently neutralized RSV A and B than MEDI7510. This enhanced response was mediated by the presence of antibodies that could bind sites on the F protein that were only present in the Pre-F state."
#RSV #RespiratorySyncytialVirus #Immunology #Vaccine
https://www.science.org/doi/abs/10.1126/scitranslmed.ade0424
@cyrilpedia That's neat, I would have thought the reverse, but none of the old vaccines have really worked on a large scale. I love it when I can understand the science blurb.
