Chemists, biochemists, pharmacologists, etc., I seek a piece of practical advice. I have a neuroactive compound that I need to get dissolved in 10 ml of weak salt water so I can expose frog cells to it. What is the best way to get rid of the methanol it comes in? I can evaporate it off but I worry that the drug dries to the sides of the tube and never goes into solution when I put water in it (i.e., I can't tell if there's anything in the water at the end or not). Any ideas?
@drmichaellevin can’t you add the compound and methanol to the salt water and then heat it all to 155f to distill out the methanol?
@kws Could do, I'm worried the heat will kill the compound, but I'll try it!
@drmichaellevin @kws Rotovaping will allow you to remove the methanol over relatively low heat, (I think 30-40 C is sufficient under a vacuum to remove the methanol IIRC, but you may need to check a methods paper for it).
