I walk in to my local Shoppers Drug Mart yesterday.
A woman stands at the other end of the counter from me, hacking & coughing away. Obviously quite ill
I am in my #P100 #elastomeric half mask, worrying that I don't have my full face #respirator on
All the pharmacy staff and other customers are completely unmasked.
I have to go back in today, its now time to step up to full face again.
This is never going to end.
@EricCarroll Time to be snorting the Enovid like you’re Don Jr. with cocaine in a spray bottle.
@edsuom Does that actually work? Its very expensive and hard to get...
Sinus lavage was recommended to me well prior to covid by an ENT for other reasons. I have restarted it in these COVID times.
I am have confidence in my elastomeric P100 PPE.
@EricCarroll @edsuom caution on long-term use though. NO2 releases free radicals. Would like to see studies if used for a long time.
@White_Bite @EricCarroll @edsuom
This is a common misconception that I've seen a lot. Being a chemist I try to clear it up when I see it.
Enovid is also known as NONS, or Nitric Oxide(NO) Nasal Spray. It is not Nitrogen Dioxide(NO2).
@White_Bite @EricCarroll @edsuom
Definitely not in my wheelhouse. I just see there's a lot of confusion on this point. People go look up NO2 and find out it's a smelly, brown gas commonly found in air pollution and wonder why it's used in medicine.
From the hour or so I spent looking at it a few months ago I know it's used in ventilation of newborns, so I suspect that over that time period it's probably quite well studied. That's also much, much higher amounts than I suspect you're talking in a quick nasal spray. High dose for short time vs small dose for longer time of NO is way outside of my knowledge base.
I've never dug into it much further than that, but if you do from your background and knowledge base, please share!
@BE @EricCarroll @edsuom thanks for the info. I did read about an initial study on animals and in vitro study on cell lines using a cyclodextrin platform and results show that max usage is around 7 days but further studies warranted
Re in vitro testing, they used a cell line that would address mechanisms of viral entry via the endosomal route. Not sure if this is the only route that Enovid addresses. If so, that's pretty limited IMO. 1/
@BE @EricCarroll @edsuom
Genuinely curious. Link to pdf of study on ss since phone won't allow me to c/p link. Would appreciate your thoughts on this since I yet have to really find a study on toxicity.
😊
@BE @EricCarroll @edsuom and one more thing, if indeed viricidal and bactericidal (although that's been proven) won't that disturb microflora in nasal cavity after prolonged or frequent use?
@White_Bite @EricCarroll @edsuom
Let me weigh in with another bit of the little info I do have. I woke up in the middle of the night thinking about this from when I looked it up previously.
Your paranasal sinuses are producers of NO. Again, concentrations of that vs what Enovid produces are unclear to me. Perhaps that data's out there. However, I do remember one doctor(perhaps correctly or perhaps wrongly) saying that humming produces more NO than Enovid. So, here's link on humming and NO production in your sinuses:
@BE @White_Bite @edsuom well learn something new every day...
@BE @EricCarroll @edsuom thank you so much! Greatly appreciated. Am so careful before accepting initial studies tbh. We don't want another Ivermectin issue -- something that could have had potential but was so badly mismanaged. (Not recommending it definitely, btw. Not at its present state.)
@BE @EricCarroll @edsuom thank you. In terms of safety for prolonged use, would you have a paper for this? Would greatly appreciate it. Thank you.