A mind-blowing paper from Dr. Bin Zhou lab🤯

Genetically Labeling/Tracing Cell Contact events & post-contact consequences

Tigre-SynNotch + Cre & Dre tri-transgenic🐭

One can track Ongoing+History of Contact (likely minimal 2-h) b/w any 2 cell types

Embryonic Cardiac #EndothelialCell not only constitutes 20% of Liver vessels but also colonizes Skeletal muscle (~5% Fig S11B)

How will this contact tracking system revolutionize our research?😄

Dendritic cell-> atherogenic SMC?
Senescent pericyte->Capillary shear sensing?

https://www.science.org/doi/10.1126/science.abo5503