SM22+ #SmoothMuscleCell LRP1 KO->

Spontaneous #SuperiorMesentericArtery Aneurysm

Baseline+Injured carotid arterial defect
(Intensive neointimal Elastin deposits!😈)

⏫Angiotensin+TGFβ signals

Dr. Alan Daugherty & Dudley Strickland labs @JCI_insight 2022
https://insight.jci.org/articles/view/164751

There is a long research history on LRP1 with SMC & arterial wall integrity, starting with this👇

LRP: Role in Vascular Wall Integrity and Protection from Atherosclerosis

Dr. Joachim Herz lab Science 2003
https://www.science.org/doi/10.1126/science.1082095