Apold1, a #EndothelialCell-enriched gene, in pathological #Angiogenesis
#LimbIschemia ⏬Reperfusion (3 dpi🤓)-> An arteriogenic defect?
#Stroke ⏫border zone vascularization at day 21 but not day 7
Tumor ⏫Nonproductive angiogenesis-> more non-perfusable endothelial channels

Apold1 KO⏬EC Proliferation-How😁

@bohaceklab@nerdculture.de & Katrien de Bock bioRxiv 2022
https://www.biorxiv.org/content/10.1101/2022.12.02.518829v1

Also very interesting, Apold1 KO->⏫KLF2 & KLF4 in EC

Apold1 is recently identified as an ascending aortic EC-enriched gene (vs descending aorta/carotid artery)
Dr. Thomas Quertermous lab bioXRiv 2022
https://www.biorxiv.org/content/10.1101/2022.05.18.492517v1.full

Are Apold1 KO mice ready for #Atherosclerosis/#Aneurysm?