#Sirt6 #Osteoarthritis

Sirt6⏬#Senescence & IL15-JAK3-STAT5-inflammation in adult #Chondrocyte

Deacetylated STAT5 by Sirt6 fails nuclear import

In contrast, Sirt6⏫p21->Senescence in embryonic chondrocyte

Dr. Ming-liang Ji & Jun Lu lab Nature Comms 2022
https://www.nature.com/articles/s41467-022-35424-w

An interesting chondrotrophic nanoparticle is used to deliver MDL-800, Sirt6 activator, in🐭DMM #Osteoarthritis

Chondrocyte-specific aptamer tgg2-functionalized PEGylated PAMAM nanoparticle

Originally used for microRNA Annals of the Rheumatic Diseases 2021
https://ard.bmj.com/content/80/3/356.abstract