Aberrant Mechanical tension-activated TGFβ1-SMAD2/3 signaling, synergized with Cdc42 deficiency, in AT2 alveolar cells causes peripheral-to-center progression #PulmonaryFibrosis in🐭post-lung lobe resection

Dr. Jingyu Chen & Nan Tang labs @cellpress 2019
https://www.cell.com/cell/fulltext/S0092-8674(19)31284-X

Interesting, ablation of TGFβR2 in Cdc42 KO AT2 cells blunts fibrotic expansion w/o rescuing #AlveolarRegeneration

In contrast, Normalizing the ectopic mechanical tension post-lung lobe resection, using a unique silicon prosthesis, rescues both alveolar regeneration & fibrosis

How Cdc42 controls AT2 cell mechanosensitivity & plasticity during #AlveolarRegeneration?

A Cdc42-F-actin-JNK/p38-YAP cascade

A very cool paper🤠👇

Dr. Nan Tang lab @CellReports 2016
https://www.cell.com/cell-reports/fulltext/S2211-1247(16)30919-6