Stabilizing FOXF1 to treat #AlveolarCapillaryDysplasia
Chemical screening->TanFe
⏬Ubiquitination of FOXF1 via⏬binding to #E3Ligase HECTD1/SHPRH/NEURL1B etc->
Restoring Lung #Angiogenesis of Foxf1+/-🐭
Dr. Vladimir Kalinichenko lab Am J Respir Crit Care Med 2022
https://www.atsjournals.org/doi/10.1164/rccm.202207-1332OC
How FOXF1 impacts #EndothelialCell #Angiogenesis?
As a transcription factor for S1PR1 & VE-Cad😎
An excellent story from Dr. Vladimir Kalinichenko lab @scisignal 2016👇
FOXF1 maintains endothelial barrier function and prevents edema after lung injury
https://www.science.org/doi/10.1126/scisignal.aad1899
Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins, due to FOXF1 heterozygous mutation, has very complex Lung & ex-Lung vascular phenotypes
A few reads🤠
https://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-020-00972-6
https://www.nature.com/articles/jp201494
https://www.nature.com/articles/ejhg2012171
https://www.jpeds.com/article/S0022-3476(04)00647-X/fulltext
