#EndothelialCell transcriptomic atlas of human Lung
Meta-analysis of scRNAseq datasets
6 healthy human lung studies >15k ECs, 73 subjects
Love the writing. Re-learn A-C-V zonation featuring marker gene annotation👍
Dr. Naftali Kaminski lab Circulation 2021
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.052318
Based on this important study, human lung aerocyte & general capillary EC are not best
distinguished by Car4/Apln & PLVAP/Aplnr, like in mice ??
Aerocyte: HPGD, SOSTDC1, EDNRB, TBX2
General: capillary EC: FCN3, GPIHBP1, BTNL8/9, IL7R
Also see comparative meta-analysis of mouse lung EC, 6 cohorts
Ligand-receptor connectome identify lung arterial EC as the champion secretory EC: Notch ligands, Ephrin B2, Endothelin 1, CXCL12, DKK2!
The runner-up is lymphatic EC: PDGFA, Sema3a, CCL21
A highly useful Lung cell atlas. Lots of fun
Human Lung capillary ECs are also abundant in Periaxin. Are they uptaking surfactant in lung, as myelin in brain? Or a role of Periaxin in #BloodGasBarrier?
