Targeting #EndothelialCell CXCR7(Up) or Jag1(Down) to untangle the vicious feed-forward loop b/w EC &
perivascular Macrophage driving #PulmonaryFibrosis
Mice with repeated lung injury by Bleomycin/HCl

Dr. Zhongwei Cao, Shahin Rafii & Bi-Sen Ding labs Nature Medicine 2016
https://www.nature.com/articles/nm.4035

Repeated chemical Lung injury suppresses EC CXCR7 & recruits PlGF-responsive VEGFR1+ Macrophage

Macrophage-derived Wnt3->?EC beta Catenin-Jag1-> subsequent Notch+ fibroblast expansion

This cascade is otherwise depressed in EC with normal CXCR7 level upon single injury

Can't imaging this can be elucidated in one paper😆