CXCL12/SDF-1 in Lung #EndothelialCell #BranchingMorphogenesis

CXCL12 KO->
Vaso-Hypoplasia
⏫Arterial branches
⏬Arterialɸ
⏬Artery+Capillary density

Any alterations in Airway branching & Alveologenesis?😋

Important to note that even lung capillary ECs are labeled by CXCL12-DsRed

Though EC is a major CXCL12 source in developing mouse lung, EC CXCL12 KO only has a minor vascular defect on primary branches

Dr. Jennifer Sucre & David Frank lab @Dev_journal 2022
https://journals.biologists.com/dev/article/149/21/dev200909/278588/CXCL12-defines-lung-endothelial-heterogeneity-and