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A remarkable mechanism for #DisturbedFlow disruption of #EndothelialCell Junction in #Atherosclerosis
Disturbed Flow-activated GRK2 phosphorylates #Vinculin Ser721-> a closed conformation of Vinculin
->⏬VE-cad junction
Dr. Jeng-Jiann Chiu lab Euro Heart J 2022
https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehac647/6830649
