Tie2+ #EndothelialCell Egln1/PHD2 KO mice
->Spontaneous #PulmonaryArterialHypertension as early as 1.5 mo

A cascade of EC PHD2 KO->
⏫autocrine #CXCL12->
⏫FoxM1-dependent proliferation

Dr. Zhiyu Dai lab IJMS_MDPI 2021
https://www.mdpi.com/1422-0067/22/6/3182

Also read Dr. Dai Circulation 2016🤠presenting EC PHD2 KO, causing PAH via HIF2α (not HIF1α)

PHD2 Deficiency in Endothelial Cells & Hematopoietic Cells Induces Obliterative Vascular Remodeling & Severe Pulmonary Arterial Hypertension PAH in🐭👤Through HIF2α
https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.116.021494