Striking Pulmomary #Vasculitis in #COVID19
3 case+2 Ctrl
Thickened+Broken elastin in hyalinizing arterial wall😎

Thbs1-hi CD163+ non-canonical Monocyte in fatal COVID! To activate platelet only?🧐
Dr. Kiyoshi Hirahara & Toshinori Nakayama labs PNAS 2022
https://www.pnas.org/doi/10.1073/pnas.2203437119

Plasma MYL9 level corr. with COVID severity!

And look at these crazy MYL9/12+ thrombi in small pulmonary arteries😬

What's the role of MYL9, a #SmoothMuscleCell contractile protein, in platelets?

This leads me into another wonderland (🐰hole)

Platelet-deposited MYL9/12 as Luminal scaffold guiding T-cell migration!?😈

Dr. Toshinori Nakayama lab Sci Immunology 2016
https://www.science.org/doi/10.1126/sciimmunol.aaf9154

Another intriguing paper on leukocyte vs arterial mural cell-derived MYL9/12 & #Vasculitis 😆

Increased Myosin light chain 9 expression during #KawasakiDisease Vasculitis

Dr. Motoko Kimura & Hiromichi Hamada labs Front Immunol 2022
https://www.frontiersin.org/articles/10.3389/fimmu.2022.1036672/full