#Autophagy #Mechanobiology

#CyclicStretch 10% 1.25Hz->
Microtubule depolymerization in venous SMC->
⏬autophagosome-lysosome fusion->
⏫p62 aggregate, binding to KEAP1->
⏫NRF2 antioxidant pathway->
⏫Vein Graft Stenosis

Dr. Ying-Xin Qi lab JMCC 2022
https://www.jmcc-online.com/article/S0022-2828(22)00534-X/fulltext