Mechano-vulnerability of #EndothelialCell in #Atherosclerosis 🤠

EVA1A, elevated by #DisturbedFlow-Twist1 axis, blocks EC #Autophagy & induces #Apoptosis

Dr. Paul Evans & Jovana Serbanovic-Canic lab ATVB 2023
https://www.ahajournals.org/doi/10.1161/ATVBAHA.122.318110

Interesting to note that LC3B in EC +72 h #DisturbedFlow is mostly lipidated (Fig. 4A)

Does this suggest that endothelium under #DisturbedFlow enter an Autophagy-dependent state? For Survival, Shear-sensing & Secretion? 🧐