Macrophage MMP12 deficiency->

⏫Alternative Complement activation
⏫Neutrophil Elastase
⏫Elastin loss
-> ⏫#AbdominalAorticAneurysm

MMP12 mainly acts more as a complement modulator (Cut C3/5?) than elastase in AAA

Dr. Mehran Sadeghi lab Circ Res 2023
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.322096

Enjoy the Discussion section. Complement system is complex & charming

Fig 1F, 6D, I guess that some stainings were done on adjacent sections?🤪